Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine
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منابع مشابه
Novel conformationally constrained analogues of agomelatine as new melatoninergic ligands.
Novel conformationally restricted analogues of agomelatine were synthesized and pharmacologically evaluated at MT₁ and MT₂ melatoninergic receptors. Replacement of the N-acetyl side chain of agomelatine by oxathiadiazole-2-oxide (compound 3), oxadiazole-5(4H)-one (compound 4), tetrazole (compound 5), oxazolidinone (compound 7a), pyrrolidinone (compound 7b), imidazolidinedione (compound 12), thi...
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Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melato...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2020
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2020.112078